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Selected publications


  • Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Ma, S., Lapin, D., Liu, L., Sun,Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J.E., Chai, J. Science. 2020, Vol 370, Issue 6521, eabe3069
  • Structural biology of plant defence. Wen Song, Alexander Forderer, Dongli Yu, Jijie Chai. The New Phytologist. 02 Sep 2020: 10.1111/nph.16906
  • Mechanistic Insight into Antiretroviral Potency of 2′-Deoxy-2′-β-fluoro-4′-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. Li Sun, Youmei Peng, Wenquan Yu, Yan Zhang, Lan Liang, Chuanjun Song, Jiao Hou, Yan Qiao, Qingduan Wang, Jingyu Chen, Mengli Wu, Dongwei Zhang, Ertong Li, Zhifu Han, Qingxia Zhao, Xia Jin, Bailing Zhang, Zhiwei Huang, Jijie Chai, Jian-Hua Wang and Junbiao Chang. Journal of Medical Chemistry. 17. Jul 2020: 63, 15, 8554–8566
  • Molecular actions of NLR immune receptors in plants and animals. Jizong Wang & Jijie Chai. Science China Life Sciences. 28 June 2020: 63, 1–14
  • Door to the cell for COVID-19 opened, leading way to therapies. Zhiwei Huang & Jijie Chai. Signal Transduction and Targeted Therapy. 26. June 2020: 5, 104
  • Resistosome and inflammasome: platforms mediating innate immunity. Yehui Xiong, Zhifu Han, JijieChai. Current Opinion in Plant Biology. 14. June 2020: Volume 56, 47-55
  • Atomic-resolution view of complete TCR-CD3 revealed. Jijie Chai. Protein Cell 06. Jan 2020: 11, 158–160
  • ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem. Liang Zhang, Daniel DeGennaro, Guangzhong Lin, Jijie Chai, Elena D. Shpak. bioRxi 25. Feb 2020
  • Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Menghang Huang, Xiaoxiao Zhang, Toh Gee Ann, Qin Gong, Jia Wang, Zhifu Han, Bin Wu, Franklin Zhong, Jijie Chai. bioRxi. 15. Aug 2020


  • Mechanisms of RALF peptide perception by a heterotypic receptor complex. Xiao Y, Stegmann M, Han Z, DeFalco T, Parys K, Xu L, Belkhadir Y, Zipfel C, Chai J. Nature. 2019.                                                                       
  • Reconstitution and structure of a plant NLR resistosome conferring immunity. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang H, Zhou J, Chai J. Science. 2019 364 (6435) eaav5870.
  • Ligand-triggert allosteric ADP release primes a plant NLR complex. Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang H, Zhou J, Chai J. Science. 2019 364 (6435) eaav5868.                                                                                      


  • The CLE9/10 secretory peptide regulates stomatal and vascular development through distinct receptors. Qian P, Song W, Yokoo T, Minobe A, Wang G, Ishida T, Sawa S, Chai J, Kakimoto T. Nature Plants. 2018, 4, 1071-1081.


  • Ma R, Han Z, Hu Z, Lin G, Gong X, Zhang H, Nasrallah JB, Chai J. Structural basis for specific self-incompatibility response in Brassica. Cell Res. 2016 26(12), 1320-1329.
  • Song W, Han Z, Wang J, Lin G, Chai J. Structural insights into ligand recognition and activation of plant receptor kinases. Curr Opin Struct Biol. 2016, 43:18-27.
  • Zhang H, Han Z, Song W, Chai J. Structural Insight into Recognition of Plant Peptide Hormones by Receptors. Mol Plant. 2016, 9(11):1454-1463
  • Hu Z, Chai J. Structural Mechanisms in NLR Inflammasome Assembly and Signaling. Curr Top Microbiol Immunol. 2016, 397:23-42.
  • Zhang H, Lin X, Han Z, Wang J, Qu LJ, Chai J. SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development. Mol Plant. 2016, 9(10):1406-1414
  • Song W, Liu L, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z, Guo H, Chai J. Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res. 2016, 26(6):674-85.
  • Meng X, Zhou J, Tang J, Li B, de Oliveira MV, Chai J, He P, Shan L. Ligand-Induced Receptor-like Kinase Complex Regulates Floral Organ Abscission in Arabidopsis. Cell Rep. 2016, 4(6):1330-8.


  • Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J. Structural and Biochemical Basis for Induced Self-propagation of a NOD-like Receptor. Science. 2015, 350(6259):399-404.
  • Wang J, Li H, Han Z, Zhang H, Wang T, Lin G, Chang J, Yang W, Chai J. Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature. 2015, 525(7568):265-8.
  • Albert I, Böhm H, Albert M, Feiler CE, Imkampe J, Wallmeroth N, Brancato C, Raaymakers TM, Oome S, Zhang H, Krol E, Grefen C, Gust AA, Chai J, Hedrich R, Van den Ackerveken G, Nürnberger T.An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants. 2015, 1:15140.
  • Tang J, Han Z, Sun Y, Zhang H, Gong X, Chai J. Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell Res. 2015, 25(1):110-20.


  • Structural insights into the activation of plant receptor kinases. Han Z, Sun Y, Chai J. Curr Opin Plant Biol. 2014 Aug; 20:55-63                                                                                                                                                                   


  • Sun Y, Han Z, Tang J, Hu Z, Chai C, Zhou B, Chai J. Structure reveals that BAK1 as a co-receptor recognizes the BRI1-bound brassinolide. Cell Res. 2013, 23(11):1326-9
  • Sun Y, Li L, Macho AP, Han Z, Hu Z, Zipfel C, Zhou JM, Chai J. Structural Basis for flg22-Induced Activation of the Arabidopsis FLS2-BAK1 Immune Complex. Science, 2013, 341(6142):172-5.
  • Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y, Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J. Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 2013 Jul 12; 341(6142):172-5.


  • Liu T, Liu Z, Song C, Hu Y, Han Z, She J, Fan F, Wang J, Jin C, Chang J, Zhou JM, Chai J. Chitin-induced dimerization activates a plant immune receptor. Science 2012, 336(6085):1160-4.                                               


  • She, J., Hanm Z., Kim, T.W., Wang, J., Cheng, W., Chang, J., Shi, S., Wang, J., Yang, M., Wang, Z.Y. and Chai, J. Structural insight into brassinosteroid perception by BRI1. Nature 474, (2011), 472-476.


  • Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010, 464 (7292): 1205-09.                   


  • Xing W, Zou Y, Liu Q, Liu J, Luo X, Huang Q, Chen S, Zhu L, Bi R, Hao Q, Wu JW, Zhou JM, Chai J. The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature 2007, 449(7159):243-7.


  • Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y. Structural basis of caspase-7 inhibition by XIAP. Cell 2001, 104(5):769-80.                                                                                            


  • Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 2000, 406(6798):855-62.